Glaucoma Horizons

Shear stress-triggered nitric oxide release from Schlemm’s canal cells

Ashpole NE, Overby DR, Ethier CR, Stamer WD.
Invest Ophthalmol Vis Sci. 2014;55(12):8067-8076.

Glaucoma Horizons

Role of nitric oxide in murine conventional outflow physiology

Chang JYH, Stamer WD, Bertrand J, et al.
Am J Physiol Cell Physiol. 2015;309(4):C205-C214.

Glaucoma Horizons

Shear stress in Schlemm’s canal as a sensor of intraocular pressure

McDonnell F, Perkumas KM, Ashpole NE, et al.
Sci Rep. 2020;10(1):5804.

Glaucoma Horizons

Shear stress-triggered nitric oxide release from Schlemm’s canal cells

Ashpole NE, Overby DR, Ethier CR, Stamer WD.
Invest Ophthalmol Vis Sci. 2014;55(12):8067-8076.

Glaucoma Horizons

Role of nitric oxide in murine conventional outflow physiology

Chang JYH, Stamer WD, Bertrand J, et al.
Am J Physiol Cell Physiol. 2015;309(4):C205-C214.

Glaucoma Horizons

Shear stress in Schlemm’s canal as a sensor of intraocular pressure

McDonnell F, Perkumas KM, Ashpole NE, et al.
Sci Rep. 2020;10(1):5804.

Glaucoma Horizons

Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma

Buys ES, Potter LR, Pasquale LR, Ksander BR.
Front Mol Neurosci. 2014;7:38.

Glaucoma Horizons

The ability of nitric oxide to lower intraocular pressure is dependent on guanylyl cyclase

Muenster S, Lieb WS, Fabry G, et al.
Invest Ophthalmol Vis Sci. 2017;58(11):4826-4835.

Glaucoma Horizons

Current understanding of conventional outflow dysfunction in glaucoma

Stamer WD, Acott TS.
Curr Opin Ophthalmol. 2012;23(2):135-143.

Glaucoma Horizons

Increased stiffness and flow resistance of the inner wall of Schlemm’s canal in glaucomatous human eyes

Vahabikashi A, Gelman A, Dong B, et al.
Proc Natl Acad Sci U S A. 2019;116(52):26555-26563.

Glaucoma Horizons

Normal and glaucomatous outflow regulation

Acott TS, Vranka JA, Keller KE, Raghunathan V, Kelley MJ.
Prog Retin Eye Res. 2020;100897.

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Nitric oxide timeline

Explore the evolution of understanding regarding the role and function of nitric oxide in pressure regulation

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IOP and blood pressure parallel

Discover the similarities between IOP and blood pressure regulation

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IOP homeostatic feedback loop

Understand the homeostatic loop sustained by nitric oxide that promotes ocular health and function

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